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Finally, GOx was grafted onto the surface of the material through amidation reactions between the COOH and NH 2 groups under the activation effect of EDC/NHS

10.1097/01.MIB.0000435849.17263.c5 112

It is worth noting that these off-target effects may also become significant resistance factors promoting tumor progression, as targeted drugs might activate these targets to protect tumor cells [11]

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